Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis
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چکیده
منابع مشابه
Stereochemical Assignment of the Protein–Protein Interaction Inhibitor JBIR‐22 by Total Synthesis†
Recent reports have highlighted the biological activity associated with a subfamily of the tetramic acid class of natural products. Despite the fact that members of this subfamily act as protein-protein interaction inhibitors that are of relevance to proteasome assembly, no synthetic work has been reported. This may be due to the fact that this subfamily contains an unnatural 4,4-disubstitued g...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2015
ISSN: 0044-8249
DOI: 10.1002/ange.201411141